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1 out of 7
men diagnosed


Surgeries per year globally


Up to 50% have severe side effects


Up to 40% have recurrence


Prostate cancer is the most frequently diagnosed cancer among men in the United States. Nearly 91% of prostate cancers first detected in men are estimated to be clinically localized, qualifying these patients as potential candidates for radical prostatectomy. Surgery, however, often incurs major side effects, including incontinence and impotence and often prostatectomies fail to achieve a surgical cure. Innovations such as minimally invasive and robotic surgery simplified and improved the procedure, yet the clinical need is still unmet. Evolving therapy guidelines delay surgeries until the disease progresses, complicating surgical procedures. When surgery fails to cure the disease, radiation and chemotherapy are prescribed adding to side effects of the procedure. Today, this occurs in over 50% of cases.


Exo-413 is designed as a dual-purpose agent, that both fluoresces cancerous tissue to facilitate curative surgery and also ablates remaining malignant cells beyond the edge of the tumor. It is an injectable to be administered before surgery and dovetails with current surgical workflow.

Exo-413 is highly selective for the PSMA receptor, which is almost exclusively overexpressed on prostate cancer cells, and is rapidly taken up. This eliminates off-target binding and precisely defines tumor tissues for surgery.

EXO-413 fluoresces in response to excitation by light, highlighting the tumor and enabling image guided surgery. Suitable light sources are standard on many intraoperative imaging systems already on the market.

Subsequent to tumor resection, the surgeon will irradiate the intraoperative field with higher intensity light, activating remaining probe and producing reactive oxygen species that lead to cell death of any remaining cancer cells.

Image Guided Surgery

Image guided surgery (“IGS”) can potentially improve outcomes by guiding surgeons to the area of interest using radiopharmaceuticals or imaging agents. As an optical fluorescence agent, Exo-413 could provide real-time guidance to surgeons on the exact margins of the tumor. Since the agent exquisitely binds to tumor-specific biomarkers, it can minimize cutting healthy tissue and associated complications. Photodynamic therapy (“PDT”) uses focused energy to a sensitizing agent to ablate tissue. Its use in cancer is growing. Activating Exo-413 after surgery can destroy nearby migrating tumor cells, potentially minimizing cancer recurrence.

Exotome’s technology, Exo-413 is licensed from Case Western Reserve University and was developed in the laboratory of Professor James P. Basilion.

The technology is comprised of two proprietary innovations: a ligand and a theranostic optical imaging agent.


Results from multiple in-vivo preclinical studies reveal that all mice whose tumors were resected under normal surgical conditions (“white light surgery”) had tumor recurrence and expired within 40 days. Mice whose tumors were resected under image-guided surgery had tumor recurrence and expired within 60 days.

Conversely, mice who had both resection and photodynamic therapy stayed cancer free and survived for the duration of the trials, three months or longer.

About Us

Ari Aminetzah

Executive Director

Ari is a senior pharma veteran, with executive business development roles among others at J&J and Crucell, a vaccine company sold to J&J for $2.7B. Ari also serves as advisor to the Ministry of Economic Affairs in the Netherlands, McKinsey & Co and multiple ventures in Europe and the USA. Ari serves as the CEO of AxelaRx Biosciences Inc.

Go Van Dam


CSO. Prof. Van Dam, Prof. of Surgery at Groningen University, trained at Harvard and the Mayo Clinic. Prof. van Dam has published more than 140 papers predominantly on the subject of clinical translation of optical molecular imaging.

James P. Basilion


Professor of Radiology and Biomedical Engineering at Case Western Reserve served in various positions at the NIH, Harvard Medical School/MGH, and  Variagenics Inc. Prof. Basilion is the immediate past-president of the World Molecular Imaging Society.

Tessa Aminetzah

Marketing & Communications Manager

Tessa has a double degree in International Business and Management both from Eastern Kentucky University and Avans Hogeschool in Breda, the Netherlands. She has presented at the Academy of Business Research conference and excels in strengthening marketing efforts of startup ventures both in Europe and the US.

Advisory Board

Prof. ben Feringa
Molecular imaging – Nobel Laureate Chemistry 2016
Prof. Michael Bouvet
Surgical oncology, UCSD, MD Anderson Cancer Center
Prof. Eben Rosenthal MD, PhD
Surgery/Radiology, Stanford Cancer Center


AxelaRx Biosciences

AxelaRx is a US-based accelerator dedicated to accelerating next-generation therapeutics by applying molecular imaging techniques, micro-dose based technology and industry expertise.

Tracer CRO BV

TRACER is the world’s leading molecular imaging-based CRO. By utilizing a proprietary micro-dose based methodology TRACER reduces the development path and time-to-market of new therapeutics by 50% from an average of seven years to an average of four years.

Recent Events & Publications

Cleveland Clinic Amp’d – Oct 21


AMP’D Arena, at the 2019 Medical Innovation Summit, will feature 40 innovative startup companies that are leading the way in best-in-class healthcare technology poised to impact the way we care for patients, [...]

Photodynamic Therapy Is an Effective Adjuvant Therapy for Image-Guided Surgery in Prostate Cancer


Photodynamic Therapy Is an Effective Adjuvant Therapy for Image-Guided Surgery in Prostate Cancer Xinning Wang1, Gopolakrishnan Ramamurthy2, Aditi A. Shirke1, Ethan Walker1, Joey Mangadlao2, ZiyingWang1, YuWang2, Lingpeng Shan3, Mark D. Schluchter3, Zhipeng Dong4, Susann M. Brady-Kalnay5, Natalie K. Walker6, Madhusudhana Gargesha7, Gregory MacLennan8, Dong Luo2, [...]

Development of targeted near-infrared imaging agents for prostate cancer


Development of targeted near-infrared imaging agents for prostate cancer. Wang X, Huang SS, Heston WD, Guo H, Wang BC, Basilion JP. Mol Cancer Ther. 2014 Nov;13(11):2595-606. doi: 10.1158/1535-7163.MCT-14-0422. Epub 2014 Sep 19. PMID: 25239933

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Exotome has operations in Cleveland, Ohio and San Diego, California.

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